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Gray Lab - Cancer Chemical Biology

Nathanael Gray Lab - Cancer Chemical Biology

Welcome to Nathanael Gray Lab

The Gray Laboratory develops first-in-class chemical probes that are used to gain new biological insights into cellular processes that drive cancer and other diseases, and to pharmacologically validate potential clinically relevant targets. ​ We take an integrative approach that combines medicinal chemistry, structural biology, biochemistry​ and molecular and cell biology to develop new therapeutic strategies.  Our work has contributed to several approved and clinical stage drugs targeting BCR-ABL, Sphingosine-1-phosphate receptor (S1PR), EGFR, EML4-ALK and CDK7. We have also developed numerous widely used chemical probes.


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©2018 Nathanael Gray Lab at Dana-Farber Cancer Institute