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Gray Lab - Cancer Chemical Biology

Nathanael Gray Lab - Cancer Chemical Biology

Gray Laboratory Probe Resources

The Gray lab believes in an open-source drug discovery model and we attempt to make all of our published compounds available to the research community.  Making the probe compounds generally available greatly diversifies and amplifies the discoveries that are made.  Click on the compound/target of interest and the datasheet has all the relevant information about the probe including commercial sources.  If no commercial source is listed or if you need to obtain large quantities, please email a request to Jinhua Wang (Jinhua_wang@dfci.harvard.edu) and include your use, mailing address and federal express account number.
 
We also generate a list of current best-in-class tool inhibitors for kinases (below downloadable pdf file) based on peer review publication and patents. The kinases are listed alphabetically. Their kinase families are shown by background colors. If you have any comments, please email to Jinhua Wang (Jinhua_wang@dfci.harvard.edu).
Download pdf of tool inhibitors


Targets for Inhibitors

Ack1
Bcr-Abl

c-Arg
CDK13
DNA-PK
FLT3
KRAS
​​​MLK1
​NUAK2

​​Src+gatekeeper mutants

ATM
BMX

CDK7
CDK14
EGFR
​HIPK2
​LRRK2
​​MNK2
​​PDGFR

​SRPK

ATR
BTK

CDK8
cKit
Erk5
​JAK3

​​MALT1
​​​​Mps1
​PI3K
​​​TAK1

Aurora
c-Abl
CDK12
DDR
FGFR
​JNK
​​
​MAP4K2
​​
​mTor
​​​SIK

Targets for Degraders

ALK
CDK4

​​FKBP12F36V
​BRD4
​CDK6
​Tau
BRD9
CDK9
​
​TRIM24
BTK
CDK10


Probes

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​Probe-ACK1-B19​

Target: Ack1 

Availability:

Data sheet for Probe-ACK1-B19:
probe-ack1-b19.pdf
File Size: 117 kb
File Type: pdf
Download File


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Probe-ALW-II-49-7
​

Target: DDR2

Availability:

Data sheet for Probe-ALW-II-49-7:
probe-alw-ii-49-7.pdf
File Size: 303 kb
File Type: pdf
Download File


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​Probe-Aurora-compound 1


Target: Aurora A/B/C

Availability:

Data sheet for Probe-Aurora-compound 1:
probe-aurora-compound_1.pdf
File Size: 126 kb
File Type: pdf
Download File


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​
​Probe-BMK1-XMD8-92

Target: Erk5

Availability: Tocris Bioscience
                        MedChem Express

Data sheet for Probe-BMK1-XMD8-92:
probe-bmk1-xmd8-92.pdf
File Size: 126 kb
File Type: pdf
Download File


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​Probe-BMX-IN-1

Target: BMX, BTK

Availability: MedChem Express

Data sheet for ​Probe-BMX-IN-1:
probe-bmx-in-1.pdf
File Size: 187 kb
File Type: pdf
Download File


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​

​Probe-CVM-6-139-1

Target: HIPK2
probe-cvm-6-139-1.pdf
File Size: 231 kb
File Type: pdf
Download File


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Probe-DDR1-IN-1


Target: DDR1

Availability:

Data sheet for Probe-DDR1-IN-1:
probe-ddr1-ddr-in-1.pdf
File Size: 159 kb
File Type: pdf
Download File


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Probe-FIIN-1

Target: FGFR 1/2/3/4

Availability:

Data sheet for Probe-FIIN-1:
probe-fiin-1.pdf
File Size: 165 kb
File Type: pdf
Download File


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Probe-FIIN-2

Target: FGFR

Availability:

Data sheet for Probe-FIIN-2:
probe-fgfr-fiin-2.pdf
File Size: 241 kb
File Type: pdf
Download File


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Probe-FIIN-3

Target: FGFR and EGFR

Availability:

Data sheet for Probe-FIIN-3:
probe-fgfr_egfr-fiin-3.pdf
File Size: 227 kb
File Type: pdf
Download File


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Probe-FMF-01-086-2
​

Target: Aurora A/B/C

Availability:

Data sheet for Probe-FMF-01-086-2:
probe-fmf-01-086-2.pdf
File Size: 349 kb
File Type: pdf
Download File


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Probe-FMF-02-063-1
​

Target: PI3K

Availability:

Data sheet for Probe-FMF-02-063-1:
probe-fmf-02-063-1.pdf
File Size: 462 kb
File Type: pdf
Download File


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Probe-FMF-03-145-1
​

Target: Aurora A/B/C

Availability:

Data sheet for Probe-FMF-03-145-1:
probe-fmf-03-145-1.pdf
File Size: 262 kb
File Type: pdf
Download File


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Probe-FMF-04-159-2
​

Target: CDK14

Availability:

Data sheet for Probe-FMF-04-159-2:
probe-fmf-04-159-2.pdf
File Size: 253 kb
File Type: pdf
Download File


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Probe-FRF-01-116
​

Target: KRAS G12C

Availability:

Data sheet for Probe-FRF-01-116:
probe-frf-01-116.pdf
File Size: 211 kb
File Type: pdf
Download File


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Probe-GNF-5


Target: Bcr-Abl, c-Abl, c-Arg

Availability: EMD
                        Medchem Express

Data sheet for Probe-GNF-5:
probe-gnf-5.pdf
File Size: 135 kb
File Type: pdf
Download File


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Probe-HG-7-85-01

Target: Bcr-Abl, PDGFR, cKit, Src+gatekeeper mutants

Availability:

Data sheet for Probe-HG-7-85-01:
probe-hg-7-85-01.pdf
File Size: 232 kb
File Type: pdf
Download File


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Probe-HG-10-102-01

Target: LRRK2, MNK2, MLK1

Availability: EMD
                        Medchem Express

Data sheet for Probe-HG-10-102-01:
probe-hg-10-102-01.pdf
File Size: 134 kb
File Type: pdf
Download File


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Probe-HTH-02-006
Target: NUAK2

Availability: 

Data sheet for Probe-HTH-02-006:
probe-hth-02-006.pdf
File Size: 264 kb
File Type: pdf
Download File


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Probe-JH-II-127
​

Target: LRRK2

Availability: Tocris

Data sheet for Probe-JH-II-127:
probe-jh-ii-127.pdf
File Size: 187 kb
File Type: pdf
Download File


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Probe-JH-IX-179
​

Target: FLT3

Availability: Medkoo Biosciences

Data sheet for Probe-JH-IX-179:
probe-jh-ix-179.pdf
File Size: 285 kb
File Type: pdf
Download File


Picture
Probe-JH-XI-05-01
​

Target: SRPK

Availability: 

Data sheet for Probe-JH-XI-05-01:
probe-jh-xi-05-01.pdf
File Size: 235 kb
File Type: pdf
Download File


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Probe-JH-XI-10-02
​

Target: CDK8

Availability: 

Data sheet for Probe-JH-XI-10-02:
probe-jh-xi-10-02.pdf
File Size: 327 kb
File Type: pdf
Download File


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Probe-JNK-IN-8

Target: JNK1/2/3

Availability: EMD
                        Medchem Express

Data sheet for Probe-JNK-IN-8:
probe-jnk-in-8.pdf
File Size: 125 kb
File Type: pdf
Download File


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Probe-JWG-071

Target: ERK5

Availability:

Data sheet for Probe-JWG-071:
probe-jwg-071.pdf
File Size: 238 kb
File Type: pdf
Download File


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Probe-LRRK2-IN-1

Target: LRRK2, Erk5

Availability: EMD
                        Medchem Express

Data sheet for Probe-LRRK2-IN-1:
probe-lrrk2-in-1.pdf
File Size: 104 kb
File Type: pdf
Download File


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Probe-Mps1-IN-1


Target: Mps1

Availability:

Data sheet for Probe-Mps1-IN-1:
probe-mps1-in-1.pdf
File Size: 198 kb
File Type: pdf
Download File


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Probe-Mps1-IN-2

Target: Mps1

Availability:

Data sheet for Probe-Mps1-IN-2:
probe-mps1-in-2.pdf
File Size: 130 kb
File Type: pdf
Download File


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Probe-NG25

Target: TAK1 and MAP4K2

Availability: MedChem Express

Data sheet for Probe-NG25:
probe-tak1_map4k2-ng25.pdf
File Size: 241 kb
File Type: pdf
Download File


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Probe-SCM-02-138

Target: MALT1

Availability:

Data sheet for Probe-SCM-02-138:
probe-scm-02-138.pdf
File Size: 341 kb
File Type: pdf
Download File


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Probe-THZ1

​Target: cdk7

Availability: MedChem Express

Data sheet for Probe-THZ1:
probe-thz1.pdf
File Size: 74 kb
File Type: pdf
Download File


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Probe-THZ531
​

Target: CDK12/13

Availability: APEXBio

Data sheet for Probe-THZ531:
probe-thz531.pdf
File Size: 357 kb
File Type: pdf
Download File


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Probe-TL4-12

Target: MAP4K2

Availability:

Data sheet for Probe-TL4-12:
probe-map4k2-tl4-12.pdf
File Size: 184 kb
File Type: pdf
Download File


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Probe-TL6-144
​

Target: JAK3

Availability:

Data sheet for Probe-TL6-144:
probe-tl-6-144.pdf
File Size: 304 kb
File Type: pdf
Download File


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Probe-Torin1

Target: mTor

Availability: Tocris Bioscience
                        MedChem Express

Data sheet for Probe-Torin1:
probe-torin1.pdf
File Size: 83 kb
File Type: pdf
Download File


Picture

Probe-Torin2

Target: mTor, ATM, ATR, DNA-PK

Availability: Tocris Bioscience
                        MedChem Express

Data sheet for Probe-Torin2:
probe-torin2.pdf
File Size: 79 kb
File Type: pdf
Download File


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Probe-WZ4002

Target: T790M EGFR

Availability: MedChem Express

Data sheet for Probe-WZ4002:
probe-wz4002.pdf
File Size: 92 kb
File Type: pdf
Download File


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Probe-XY-02-082
​

Target: KRAS G12C

Availability:

Data sheet for Probe-XY-02-082:
probe-xy-02-082.pdf
File Size: 237 kb
File Type: pdf
Download File


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Probe-YKL-01-116
​

Target: CDK7

Availability:

Data sheet for Probe-YKL-01-116:
probe-ykl-1-116.pdf
File Size: 369 kb
File Type: pdf
Download File


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Probe-YKL-05-099
​

Target: SIK1/2

Availability: MedChem Express

Data sheet for Probe-YKL-05-099:
probe-ykl-05-099.pdf
File Size: 314 kb
File Type: pdf
Download File


Picture
Probe-YKL-05-124
​

Target: CDK7

Availability: 

Data sheet for Probe-YKL-05-124:
probe-ykl-5-124.pdf
File Size: 362 kb
File Type: pdf
Download File


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Probe-YKL-06-061
​

Target: SIK1/2

Availability:

Data sheet for Probe-YKL-06-061:
probe-ykl-06-061.pdf
File Size: 195 kb
File Type: pdf
Download File


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Probe-BSJ-03-123
​

Target: CDK6

Availability:

Data sheet for Probe-BSJ-03-123:
probe-bsj-03-123.pdf
File Size: 232 kb
File Type: pdf
Download File


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Probe-BSJ-03-204
​

Target: CDK4/6

Availability:

Data sheet for Probe-BSJ-03-204:
probe-bsj-03-204.pdf
File Size: 227 kb
File Type: pdf
Download File


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Probe-BSJ-04-132
​

Target: CDK4

Availability:

Data sheet for Probe-BSJ-04-132:
probe-bsj-04-132.pdf
File Size: 225 kb
File Type: pdf
Download File


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Probe-dBET6
​

Target: BRD4

Availability:

Data sheet for Probe-dBET6:
probe-dbet6.pdf
File Size: 323 kb
File Type: pdf
Download File


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Probe-dBRD9
​

Target: BRD9

Availability:

Data sheet for Probe-dBRD9:
probe-dbrd9.pdf
File Size: 241 kb
File Type: pdf
Download File


Picture
Probe-dBRD9-A
​

Target: BRD9

Availability:

Data sheet for Probe-dBRD9-A:
probe-dbrd9-a.pdf
File Size: 272 kb
File Type: pdf
Download File


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Probe-DD-03-171
​

Target: BTK

Availability:

Data sheet for Probe-DD-03-171:
probe-dd-03-171.pdf
File Size: 231 kb
File Type: pdf
Download File


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Probe-dTAG-13
​

Target: FKBP12F36V

Availability:

Data sheet for Probe-dTAG-13:
probe-dtag-13.pdf
File Size: 224 kb
File Type: pdf
Download File


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Probe-dTRIM24
​

Target: TRIM24

Availability:

Data sheet for Probe-dTRIM24:
probe-dtrim24.pdf
File Size: 339 kb
File Type: pdf
Download File


Picture

Probe-QC-01-175
​

Target: Tau

Availability:

Data sheet for Probe-QC-01-175:
probe-qc-01-175-1.pdf
File Size: 256 kb
File Type: pdf
Download File


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Probe-THAL-SNS-032
Target: CDK9/10

Availability:

Data sheet for Probe-THAL-SNS-032:
probe-thal-sns_032.pdf
File Size: 215 kb
File Type: pdf
Download File


Picture
​Probe-TL13-112
Target: ALK

Availability:

Data sheet for Probe-TL13-112:
probe_-_tl13-112.pdf
File Size: 349 kb
File Type: pdf
Download File

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©2018 Nathanael Gray Lab at Dana-Farber Cancer Institute