Gray Laboratory Probe Resources
The Gray lab believes in an open-source drug discovery model and we attempt to make all of our published compounds available to the research community. Making the probe compounds generally available greatly diversifies and amplifies the discoveries that are made. Click on the compound/target of interest and the datasheet has all the relevant information about the probe including commercial sources. If no commercial source is listed or if you need to obtain large quantities, please email a request to Jinhua Wang (Jinhua_wang@dfci.harvard.edu) and include your use, mailing address and federal express account number.
We also generate a list of current best-in-class tool inhibitors for kinases (below downloadable pdf file) based on peer review publication and patents. The kinases are listed alphabetically. Their kinase families are shown by background colors. If you have any comments, please email to Jinhua Wang (Jinhua_wang@dfci.harvard.edu).
Download pdf of tool inhibitors
We also generate a list of current best-in-class tool inhibitors for kinases (below downloadable pdf file) based on peer review publication and patents. The kinases are listed alphabetically. Their kinase families are shown by background colors. If you have any comments, please email to Jinhua Wang (Jinhua_wang@dfci.harvard.edu).
Download pdf of tool inhibitors
Targets for Inhibitors
Targets for Degraders
Probes
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Probe-ACK1-B19 Target: Ack1 Availability: Data sheet for Probe-ACK1-B19: 
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Probe-ALW-II-49-7 Target: DDR2 Availability: Data sheet for Probe-ALW-II-49-7:
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Probe-Aurora-compound 1 Target: Aurora A/B/C Availability: Data sheet for Probe-Aurora-compound 1:
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Probe-BMK1-XMD8-92 Target: Erk5 Availability: Tocris Bioscience MedChem Express Data sheet for Probe-BMK1-XMD8-92:
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Probe-CVM-6-139-1 Target: HIPK2
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Probe-DDR1-IN-1 Target: DDR1 Availability: Data sheet for Probe-DDR1-IN-1:
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Probe-FIIN-1 Target: FGFR 1/2/3/4 Availability: Data sheet for Probe-FIIN-1:
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Probe-FIIN-2 Target: FGFR Availability: Data sheet for Probe-FIIN-2:
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Probe-FIIN-3 Target: FGFR and EGFR Availability: Data sheet for Probe-FIIN-3:
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Probe-FMF-01-086-2 Target: Aurora A/B/C Availability: Data sheet for Probe-FMF-01-086-2:
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Probe-FMF-02-063-1 Target: PI3K Availability: Data sheet for Probe-FMF-02-063-1:
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Probe-FMF-03-145-1 Target: Aurora A/B/C Availability: Data sheet for Probe-FMF-03-145-1:
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Probe-FMF-04-159-2 Target: CDK14 Availability: Data sheet for Probe-FMF-04-159-2:
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Probe-FRF-01-116 Target: KRAS G12C Availability: Data sheet for Probe-FRF-01-116:
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Probe-GNF-5 Target: Bcr-Abl, c-Abl, c-Arg Availability: EMD Medchem Express Data sheet for Probe-GNF-5:
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Probe-HG-7-85-01 Target: Bcr-Abl, PDGFR, cKit, Src+gatekeeper mutants Availability: Data sheet for Probe-HG-7-85-01:
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Probe-HG-10-102-01 Target: LRRK2, MNK2, MLK1 Availability: EMD Medchem Express Data sheet for Probe-HG-10-102-01:
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Probe-HTH-02-006 Target: NUAK2 Availability: Data sheet for Probe-HTH-02-006:
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Probe-JH-XI-05-01
Target: SRPK Availability: Data sheet for Probe-JH-XI-05-01:
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Probe-JH-XI-10-02
Target: CDK8 Availability: Data sheet for Probe-JH-XI-10-02:
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Probe-JWG-071
Target: ERK5 Availability: Data sheet for Probe-JWG-071:
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Probe-LRRK2-IN-1 Target: LRRK2, Erk5 Availability: EMD Medchem Express Data sheet for Probe-LRRK2-IN-1:
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Probe-Mps1-IN-1 Target: Mps1 Availability: Data sheet for Probe-Mps1-IN-1:
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Probe-Mps1-IN-2 Target: Mps1 Availability: Data sheet for Probe-Mps1-IN-2:
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Probe-SCM-02-138
Target: MALT1 Availability: Data sheet for Probe-SCM-02-138:
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Probe-TL4-12 Target: MAP4K2 Availability: Data sheet for Probe-TL4-12:
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Probe-TL6-144 Target: JAK3 Availability: Data sheet for Probe-TL6-144:
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Probe-Torin2 Target: mTor, ATM, ATR, DNA-PK Availability: Tocris Bioscience MedChem Express Data sheet for Probe-Torin2:
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Probe-XY-02-082 Target: KRAS G12C Availability: Data sheet for Probe-XY-02-082:
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Probe-YKL-01-116 Target: CDK7 Availability: Data sheet for Probe-YKL-01-116:
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Probe-YKL-05-124
Target: CDK7 Availability: Data sheet for Probe-YKL-05-124:
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Probe-YKL-06-061 Target: SIK1/2 Availability: Data sheet for Probe-YKL-06-061:
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Probe-BSJ-03-123
Target: CDK6 Availability: Data sheet for Probe-BSJ-03-123:
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Probe-BSJ-03-204
Target: CDK4/6 Availability: Data sheet for Probe-BSJ-03-204:
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Probe-BSJ-04-132
Target: CDK4 Availability: Data sheet for Probe-BSJ-04-132:
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Probe-dBET6 Target: BRD4 Availability: Data sheet for Probe-dBET6:
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Probe-dBRD9 Target: BRD9 Availability: Data sheet for Probe-dBRD9:
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Probe-dBRD9-A
Target: BRD9 Availability: Data sheet for Probe-dBRD9-A:
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Probe-DD-03-171
Target: BTK Availability: Data sheet for Probe-DD-03-171:
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Probe-dTAG-13 Target: FKBP12F36V Availability: Data sheet for Probe-dTAG-13:
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Probe-dTRIM24 Target: TRIM24 Availability: Data sheet for Probe-dTRIM24:
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Probe-QC-01-175 Target: Tau Availability: Data sheet for Probe-QC-01-175:
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Probe-THAL-SNS-032 Target: CDK9/10 Availability: Data sheet for Probe-THAL-SNS-032:
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Probe-TL13-112
Target: ALK Availability: Data sheet for Probe-TL13-112:
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